A lab in your pocket: Using CAD to load dozens of tests on a lab-on-a-chip

Two computer-generated configurations for routing a droplet through multiple lab-on-a-chip diagnostic tests, many more than are currently possible using manual methods. The software was developed by Michigan Tech's Shiyan Hu and Chen Liao. The figure is reproduced with permission of IEEE Transactions on NanoBioscience. Credit: Chen Liao and Shiyan Hu

When you get sick, your physician may take a sample of your blood, send it to the lab and wait for results. In the near future, however, doctors may be able to run those tests almost instantly on a piece of plastic about the size of credit card.

These labs-on-a-chip would not only be quick -- results are available in minutes -- but also inexpensive and portable. They could be used miles from the nearest medical clinic to test for anything from HIV to diabetes. But as powerful as they may be, they could be far better, says Shiyan Hu, an associate professor of electrical and computer engineering at Michigan Technological University.

Generally, a lab-on-a-chip (LOC) can run no more than a test or two. That's because the chips are designed manually, says Hu. If the LOC were made using computer-aided design, you could run dozens of tests with a single drop of blood.

"In a very short time, you could test for many conditions," he said. "This really would be an entire lab on a chip."

With PhD student Chen Liao, Hu has taken the first step. "We have developed software to design the hardware," he said. Their work focuses on routing the droplet of blood or other fluid through each test on the chip efficiently while avoiding any chip contamination.

"It has taken us four years to do the software, but to manufacture the LOC would be inexpensive," Hu said. "The materials are very cheap, and the results are more accurate than a conventional lab's."

Ultimately, Hu aims to fabricate their own biochip using their software.

Their work was featured on the cover of the March edition of IEEE Transactions on Nanobiosciences and described in the article "Physical-Level Synthesis for Digital Lab-On-a-Chip Considering Variation, Contamination, and Defect." Liao was partially supported by an A. Richard Newton Graduate Scholarship, awarded by the Design Automation Conference.

Source: Michigan Technological University

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Smartphone sensors leave trackable fingerprints

Example demonstrating how accelerometer data shared with separate traffic and health applications could indicate Bob's location. Credit: Image courtesy of University of Illinois College of Engineering

Fingerprints -- those swirling residues left on keyboards and doorknobs -- are mostly invisible. They can affirm your onetime presence, but they cannot be used to track your day-to-day activities.

They cannot tell someone in real time that after exercising at the gym, you went to office in a bus and played video games during lunch. But what if our hand-held electronics are leaving real-time fingerprints instead? Fingerprints that are so intrinsic to the device that, like our own, they cannot be removed?

Research by Associate Professor Romit Roy Choudhury and graduate students Sanorita Dey and Nirupam Roy has demonstrated that these fingerprints exist within smartphone sensors, mainly because of imperfections during the hardware manufacturing process.

In some ways, it's like cutting out sugar cookies. Even using the same dinosaur-shaped cutter, each cookie will come out slightly different: a blemish here, a pock there. For smartphone sensors, these imperfections simply occur at the micro- or nanoscale.

Their findings were published at the Network and Distributed System Security Symposium (NDSS), a major conference on wireless and web security, held last February in San Diego. 

The research also won the best poster award at the HotMobile international workshop in 

2013.

The researchers focused specifically on the accelerometer, a sensor that tracks three-dimensional movements of the phone -- essential for countless applications, including pedometers, sleep monitoring, mobile gaming -- but their findings suggest that other sensors could leave equally unique fingerprints.

"When you manufacture the hardware, the factory cannot produce the identical thing in millions," Roy said. "So these imperfections create fingerprints."

Of course, these fingerprints are only visible when accelerometer data signals are analyzed in detail. Most applications do not require this level of analysis, yet the data shared with all applications -- your favorite game, your pedometer -- bear the mark. Should someone want to perform this analysis, they could do so.

The researchers tested more than 100 devices over the course of nine months: 80 standalone accelerometer chips used in popular smartphones, 25 Android phones, and 2 tablets.

The accelerometers in all permutations were selected from different manufacturers, to ensure that the fingerprints weren't simply defects resulting from a particular production line.

With 96 percent accuracy, the researchers could discriminate one sensor from another.

"We do not need to know any other information about the phone -- no phone number or SIM card number," Dey said. "Just by looking at the data, we can tell you which device it's coming from. It's almost like another identifier."

In the real world, this suggests that even when a smartphone application doesn't have access to location information (by asking "this application would like to use your current location"), there are other means of identifying the user's activities. It could be obtained with an innocuous-seeming game or chatting service, simply by recording and sending accelerometer data. There are no regulations mandating consent.

To collect the data, the researchers -- as with any would-be attacker -- needed to sample the accelerometer data. Each accelerometer was vibrated using a single vibrator motor -- like those that buzz when a text message is received -- for two-second intervals. During those periods, the accelerometer detected the movement and the readings were transmitted to a supervised-learning tool, which decoded the fingerprint.

"Even if you erase the app in the phone, or even erase and reinstall all software," Roy said, "the fingerprint still stays inherent. That's a serious threat."

At this point, however, there is no absolute solution. Smartphone cases made of rubber or plastic do little to mask the signal. Deliberately injecting white noise in the sensor data can smudge the fingerprint, but such noise can also affect the operation of the application, making your pedometer inaccurate and functionally useless.

If accelerometer data were processed directly on the phone or tablet, rather than on the cloud, the fingerprint could be scrubbed before sending information to the application.

That is, the pedometer application might only receive basic information like "300 steps taken," rather than receiving the raw accelerometer data. This, however, imposes a load on the phone's processor and, more importantly, reduces the phone's battery life.

The research also suggests that other sensors in the phone -- gyroscopes, magnetometers, microphones, cameras, and so forth -- could possess the same types of idiosyncratic differences. So even if, at a large scale, the accuracy of accelerometer fingerprints diminishes, when combined with prints from other sensors, an attack could be even more precise.

"Imagine that your right hand fingerprint, by some chance, matches with mine," Roy Choudhury said. "But your left-hand fingerprint also matching with mine is extremely unlikely. So even if accelerometers don't have unique fingerprints across millions of devices, we believe that by combining with other sensors such as the gyroscope, it might still be possible to track a particular device over time and space."

For smartphone users and e-book readers, smartwatch wearers and tablet devotees, perhaps the most critical take-home message, in the short run anyway, is the importance of vigilance.

"Don't share your accelerometer data without thinking about how legitimate or how secure that application is," Dey said. "Even if it's using only the sensor data, still it can attack you in some way. The consumer should be aware."

Source: University of Illinois College of Engineering

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3-D printed Shelby Cobra

This Shelby Cobra sports car, 3D-printed at Department of Energy's Manufacturing Demonstration Facility at Oak Ridge National Laboratory, will be on display this week at the Detroit Auto Show Technology Showcase. Credit: Image courtesy of Oak Ridge National Laboratory

With a 3-D printed twist on an automotive icon, the Department of Energy's Oak Ridge National Laboratory is showcasing additive manufacturing research at the 2015 North American International Auto Show in Detroit.

ORNL's newest 3-D printed vehicle pays homage to the classic Shelby Cobra in celebration of the racing car's 50th anniversary. The 3-D printed Shelby will be on display January 12-15 as part of the show's inaugural Technology Showcase.

Researchers printed the Shelby car at DOE's Manufacturing Demonstration Facility at ORNL using the Big Area Additive Manufacturing (BAAM) machine, which can manufacture strong, lightweight composite parts in sizes greater than one cubic meter. The approximately 1400-pound vehicle contains 500 pounds of printed parts made of 20 percent carbon fiber.
Recent improvements to ORNL's BAAM machine include a smaller print bead size, resulting in a smoother surface finish on the printed pieces. Subsequent work by Knoxville-based TruDesign produced a Class A automotive finish on the completed Shelby.

"Our goal is to demonstrate the potential of large-scale additive manufacturing as an innovative and viable manufacturing technology," said Lonnie Love, leader of ORNL's Manufacturing Systems Research group. "We want to improve digital manufacturing solutions for the automotive industry."

The team took six weeks to design, manufacture and assemble the Shelby, including 24 hours of print time. The new BAAM system, jointly developed by ORNL and Cincinnati Incorporated, can print components 500 to 1000 times faster than today's industrial additive machines. ORNL researchers say the speed of next-generation additive manufacturing offers new opportunities for the automotive industry, especially in prototyping vehicles.

"You can print out a working vehicle in a matter of days or weeks," Love said. "You can test it for form, fit and function. Your ability to innovate quickly has radically changed. There's a whole industry that could be built up around rapid innovation in transportation."

The Shelby project builds on the successful completion of the Strati, a fully 3-D printed vehicle created through a collaboration between Local Motors and ORNL.

The lab's manufacturing and transportation researchers plan to use the 3-D printed Shelby as a laboratory on wheels. The car is designed to "plug and play" components such as battery and fuel cell technologies, hybrid system designs, power electronics, and wireless charging systems, allowing researchers to easily and quickly test out new ideas.

Source: Oak Ridge National Laboratory

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A new wireless energy transfer device can charge any device without using cables

Researchers have designed a new device for wireless energy transfer that will charge mobile phones or laptops without the need for wires. Credit: UPV

Researchers at the Universitat Politècnica de València (UPV) have designed a new device for wireless energy transfer that will, for example, charge mobile phones or laptops without needing wires.

The system, patented by the UPV, is based on the use of resonators designed with radial photonic crystals; one of them would act as an energy transmitter and the other would be set on the device that needed to be charged. Between them a phenomena known as resonant coupling is produced, which is what finally produces the charging or recharging of the equipment.

"This phenomena is produced when a resonant object is moved closer to a second resonant element and both resonance frequencies are equal or quite similar. This physical proximity produces an energy coupling from the first device, that acts as the source, to the second one, that acts as the charge," says José Sánchez-Dehesa, researcher at the Wave Phenomena 

Group of the Universitat Politècnica de València.

The device could also be used as a power supply system for equipment such as keyboards and wireless mice, speakers, etc. Besides consumer electronics, it could also be used in an industrial environment as power supply for robots or guided vehicles, and bioelectric devices (cardiac pacemakers, defibrillators, etc.)

The UPV researchers' study was released last June in the Annals of Physics magazine. After the first laboratory simulations and calculations of the system's performance, the engineers of the Wave Phenomena Group are now working on the development of the first prototype.

Technology implementation

With regard to the implementation of these devices, UPV researchers say that, "although it may seem futuristic, it is foreseeable that they become universal due to the spread of charging infrastructure in many settings. This technology could follow the same path as WIFI networks," explains Jorge Carbonell, researcher at the Wave Phenomena Group.

Source: Asociación RUVID

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A mobile app for conducting opinion polls

Opiner is an open source tool for opinion polling. Credit: Image courtesy of KTH The Royal Institute of Technology

Soon anyone can conduct public opinion polls to drive issues that are important to them, using a new open source tool being developed at Sweden's KTH Royal Institute of Technology.

Researcher Konrad Tollmar and his colleagues intend for the mobile app, Opiner, to be used as a tool for direct democracy. Tollmar says that once Opiner is publicly available, it will enable anyone to conduct surveys, drive public opinion and influence political decisions.

"This will be an alternative to services that can cost millions to use," says Tollmar. "It gives people an opportunity that historically only large organisations have had."

Public opinion polls are an important tool for interest groups, which regularly hire commercial firms to conduct polls for them. The ability to take stock of -- and present -- public opinion enables interest groups to control the narrative around their issues, establish their communications themes and influence how the media and policymakers grasp a given subject.

"Polling can be expensive," he says. "But Opiner enables anyone to drive public opinion or conduct surveys."

Opiner could also have the benefit of energising more people to become politically involved. And it's not just for activists. Media organisations big and small can use the tool for their own purposes.

"We're working on a form of direct democracy. That people can have a voice in society," he says.

"But Opiner can be used for just about anything, large or small," he says, noting that one of the strengths of Opiner is that it can be context-specific.

Targeting mobile devices means that Opiner pollsters can make use of both space and time 

to find out what people think, and ask relevant questions based on these two parameters. For example, what do people think about public transportation when they are riding on the subway? What do students think about the quality of lunch while they're sitting in the school cafeteria?

"There is evidence in behavioral science and what is called "Experience Sampling," that surveys get a more true result when people are asked what they think in the moment, instead of afterward," he says.

Opiner also offers transparency. In addition to implementing polls, users can analyse the performance and freely share it. The system includes a toolkit to easily visualise the results in an understandable way.

"There are a lot of great tools on the web for public polling, but they are closed and commercial. Opiner is fully open and works on all types of newer phones. The system is open source, so anyone can download the software and set up their own Opiner," he says.

But it's not just the political benefit that Tollmar hopes to spread. In beta tests with teachers and students, the research team found that the act of surveying itself serves an educational purpose: as a way of developing students understanding of politics and language.

"First, we talked with their teachers about which questions should be asked. That worked so-so," he says. "The students didn't think the questions were always relevant. It was much better when the students themselves had to formulate their questions."

Opiner is part of the European research project, FlashPoll. Flashpoll has a mature Android app available, but what makes Opiner stand-out, Tollmar says, is its truly open platform -- from the establishment of questions, running the polls and analysis, to the sharing of results. "You should rather see Opiner as a research prototype of the next generation of Flashpoll tools," he says.

Tollmar is among a group of researchers at KTH who have worked with various digital tools over the last several years to help people make their voices heard, including Måns Wrange, Patrik Hernwall, Igor Isaksson och Mats Gustavsson.

Source: KTH The Royal Institute of Technology

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That smartphone is giving your thumbs superpowers

While neuroscientists have long studied brain plasticity in expert groups--musicians or video gamers, for instance--smartphones present an opportunity to understand how regular life shapes the brains of regular people. Credit: © Antonioguillem / Fotolia

When people spend time interacting with their smartphones via touchscreen, it actually changes the way their thumbs and brains work together, according to a report in the Cell Press journal Current Biology on December 23. More touchscreen use in the recent past translates directly into greater brain activity when the thumbs and other fingertips are touched, the study shows.

"I was really surprised by the scale of the changes introduced by the use of smartphones," says Arko Ghosh of the University of Zurich and ETH Zurich in Switzerland. "I was also struck by how much of the inter-individual variations in the fingertip-associated brain signals could be simply explained by evaluating the smartphone logs."

It all started when Ghosh and his colleagues realized that our newfound obsession with smartphones could be a grand opportunity to explore the everyday plasticity of the human brain. Not only are people suddenly using their fingertips, and especially their thumbs, in a new way, but many of us are also doing it an awful lot, day after day. Not only that, but our phones are also keeping track of our digital histories to provide a readymade source of data on those behaviors.

Ghosh explains it this way: "I think first we must appreciate how common personal digital devices are and how densely people use them. What this means for us neuroscientists is that the digital history we carry in our pockets has an enormous amount of information on how we use our fingertips (and more)."

While neuroscientists have long studied brain plasticity in expert groups--musicians or video gamers, for instance--smartphones present an opportunity to understand how regular life shapes the brains of regular people.

To link digital footprints to brain activity in the new study, Ghosh and his team used electroencephalography (EEG) to record the brain response to mechanical touch on the thumb, index, and middle fingertips of touchscreen phone users in comparison to people who still haven't given up their old-school mobile phones.

The researchers found that the electrical activity in the brains of smartphone users was 

enhanced when all three fingertips were touched. In fact, the amount of activity in the cortex of the brain associated with the thumb and index fingertips was directly proportional to the intensity of phone use, as quantified by built-in battery logs. The thumb tip was even sensitive to day-to-day fluctuations: the shorter the time elapsed from an episode of intense phone use, the researchers report, the larger was the cortical potential associated with it.

The results suggest to the researchers that repetitive movements over the smooth touchscreen surface reshape sensory processing from the hand, with daily updates in the brain's representation of the fingertips. And that leads to a pretty remarkable idea: "We propose that cortical sensory processing in the contemporary brain is continuously shaped by personal digital technology," Ghosh and his colleagues write.

What exactly this influence of digital technology means for us in other areas of our lives is a question for another day. The news might not be so good, Ghosh and colleagues say, noting evidence linking excessive phone use with motor dysfunctions and pain.

Source: Cell Press

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The Ant colonies help evacuees in disaster zones

Trail of ants (stock image). Credit: © grekoff / Fotolia

An escape route mapping system based on the behavior of ant colonies could give evacuees a better chance of reaching safe harbor after a natural disaster or terrorist attack by building a map showing the shortest routes to shelters and providing regular updates of current situations such as fires, blocked roads or other damage via the smart phones of emergency workers and those caught up in the disaster.

Koichi Asakura of Daido University in Nagoya and Toyohide Watanabe of the Nagoya Industrial Science Research Institute in Japan have carried out successful simulations of the construction of navigational maps using this approach and report details in the International Journal of Knowledge and Web Intelligence. Following a major earthquake, tsunami, typhoon or other disaster it is crucial for those affected, including emergency workers, to obtain and share accurate and timely information about the situation as it unfolds. Lives can only be saved if evacuation to safe areas and shelters is not stymied by blocked roads, fires and other problems.

The team's new system has two key features: First it utilizes the smart phones that are now ubiquitous across cities as networked, mobile sensors that can feed information back to emergency centers. The second feature exploits our understanding of the behavior of an ant colony. This provides a way to determine whether or not particular problems are recent or not, just as individual ants use pheromone trails, and the concentration changes in those pheromones to assess how recently a colony member left a particular signal and so find the optimal routes to and from the nest via food supplies. By using this approach to analyze the data from myriad smart phones as evacuees head for shelter, it is possible to build an active navigational map using the phones' GPS and other tools.

The system circumvents the problem that would be almost inevitable during a disaster that closed circuit television (CCTV) cameras would be unreliable whereas sufficient numbers of wireless communication devices might remain active for sufficient time given a large enough number of service providers and communication towers spread widely across the disaster area. The next step will be to develop an ad hoc mobile networking system so that evacuees can themselves access these active maps rather than the present system that provides advice to emergency services for guiding evacuees. Such a network might also circumvent the problem of service provider outages by allowing individual smart phones to create a local network.

Source: Inderscience Publishers

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